Anti-carbonic anhydrase II antibodies in end-stage renal disease patients

ABSTRACT

The aim of this study was to investigate the presence of anti-carbonic anhydrase [CA II] autoantibodies in patients with end-stage renal disease [ESRD] and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen [BUN] and creatinine. Serum CA II autoantibody titers, malondialdehyde [MDA], BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. The CA II autoantibody titers in the ESRD group [0.170 +/- 0.237] were significantly higher than those in the control group [0.079 +/- 0.032; p = 0.035]. MDA and ghrelin levels were also significantly higher in the ESRD group [p < 0.001]. A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers [r = 0.287, p = 0.028 and r = -0.278, p = 0.032, respectively].In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti-CA II antibodies could be involved in the pathogenesis of ESRD