high performance liquid chromatographic method for studying the stability and dissolution of nifedipine from its marketed formulation in Egypt

ABSTRACT

A high performance liquid chromatographic method was developed to assay the photodegradation products of nifedipine. Using this method, the quantities of decomposition products were determined in generically equivalent brands of nifedipine retard tablets and capsules. All tablet formulation contained small quantities of the nitroso derivative of nifedipine. One capsule brand showed absence of any decomposition products. This analytical method was used to determine the dissolution rates of all brands of retard tablets. However, slight differences in the dissolution profiles among the studied brands were observed