Cytogenetic study of the effect of bentazon and glyphosate herbicide on mice

ABSTRACT

Genotoxic effect of acute and chronic doses of Bentazon and Glyphosate herbicides were estimated using micronucleus [MN], nuclear budding, mitotic index [MI] and chromosomal aberration assays. Five groups of Swiss male albino mice were used in acute exposure of 1/5 and 1/10 LD50 of both herbicides after 24, 96 hours of exposure compared to the control. For chronic exposure 1/20 of LD50 of each herbicide was for two months. Genotoxicity of acute doses at different duration of Bentazon and Glyphosate were confirmed through significant increased number of aberrant cells, different types of chromosomal aberration, micronucleus and nuclear budding. Chronic dose of Bentazone induced more genotoxic effects than Glyphosate