Clinical utility of interferon-gamma compared to ADA in tuberculous pleural effusion
Egyptian Journal of Chest Diseases and Tuberculosis [The]. 2012; 61 (4): 371-375
in English
| IMEMR
| ID: emr-160140
ABSTRACT
Tuberculosis [TB], the single most frequent infectious cause of death worldwide, also is a major cause of pleural effusion, which in TB usually has lymphocytic and exudative characteristics. Differential diagnosis between TB and nontuberculous pleural effusion can be sometimes difficult, representing a critically important clinical problem. To evaluate the clinical utility of pleural IFN-gamma level in pleural fluid for diagnosing tuberculous pleuritis. The study was conducted in kasr El-Aini hospital, Cairo University in the period from January 2011 to January 2012. It was carried on 40 patients. The patients included in the study were classified into group I [included 20 cases with tuberculous pleural effusion] and group II [included 20 cases with non tuberculous pleural effusion]. All patients were subjected for complete history taking and clinical examination, chest X-rays PA and lateral views, pleural fluid aspiration and analysis. Our results demonstrate that the pleural fluid concentrations of ADA, INF-gamma in patients with tuberculous pleural effusions are significantly higher than in other effusions. Most importantly, ROC analysis clearly demonstrated ADA to be more sensitive and specific than INF-gamma for diagnosis of tuberculous pleuritis
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Tuberculosis
/
Comparative Study
/
Adenosine Deaminase
/
Interferon-gamma
/
Hospitals, University
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Chest Dis. Tuberc.
Year:
2012
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