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CD8+T cell activation associated with viral replication in chronic infection
Egyptian Journal of Hospital Medicine [The]. 2014; 57 (October): 395-402
in English | IMEMR | ID: emr-160238
ABSTRACT
PD-1 expression is controlled during T-cell activation. PD-1 has an important role in regulating immune response as well as tolerance. During chronic hepatitis C virus [HCV] infection there is high level of PD-1 expression on exhausted CD8+T cells. There is also reduced expression of T-bet. T-bet is identified as a transcriptional repressor of Pdcd1. The study will attempt to find out the level of expression of PD-1 on peripheral CD8 + T-cells, associated with chronic HCV infection. Fifty patients with chronic hepatitis C virus infection [CHCV], whose age ranged between [16-59] years, were selected from the National Hepatology and Tropical Medicine Research Institute were included in this study, before Interferon and ribavirin therapy, and fifteen healthy individuals were included to serve as controls. All the patients and controls were subjected to the following history, clinical examination, abdominal ultrasonography and collection of blood samples for routine laboratory investigations. CBCs and analysis of the expression of surface markers on CD8+T cells and PD-1. Our results suggested that increased expression of PD-1 cells was an additional inhibitory mechanism that contributed to virus-specific CD8 + T cell exhaustion in chronic hepatitis C virus [CHCV] infected patients. Our study concluded that there's significant increase in PD-1 expression of circulating HCV-specific CD8 + T cells in CHCV patients. The blockade of the inhibitory receptors [PD-1] programmed cell death is considered as a novel strategy for the treatment of chronic HCV infection
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Index: IMEMR (Eastern Mediterranean) Main subject: Ribavirin / Treatment Outcome / Severe Combined Immunodeficiency / Interferon-alpha / Hepacivirus / Real-Time Polymerase Chain Reaction Limits: Humans Language: English Journal: Egypt. J. Hosp. Med. Year: 2014

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Index: IMEMR (Eastern Mediterranean) Main subject: Ribavirin / Treatment Outcome / Severe Combined Immunodeficiency / Interferon-alpha / Hepacivirus / Real-Time Polymerase Chain Reaction Limits: Humans Language: English Journal: Egypt. J. Hosp. Med. Year: 2014