Synthesis of novel uracil-5sulphonamide derivatives of possible biological activity
Egyptian Journal of Chemistry. 1990; 33 (4): 375-80
in English
| IMEMR
| ID: emr-16029
ABSTRACT
It has been reported that several uracil derivatives possess useful applications as anticancer agents. Also many uracil sulphonamides were found to possess inhibitory effect on the growth of Mycrnbacterium tuberculosis. On the other hand, several pyrazoles, 1, 2, 4-triazoles and pyridine derivatives were found to be bactericides, fungicides and anticancer agents. Based on these findings, it was of interest to prepare some novel uracil-5-sulphonamides linked to different heterocyclic systems namely 1, 2, 4-triazole5 5-pyrazolone and/or 3-pyridyl substituents starting with 5-[sulphonamido-p-carbethoxyphenyl] -uracil intermediate [III] in a trial to obtain compounds of possible biological activity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Biological Availability
Language:
English
Journal:
Egypt. J. Chem.
Year:
1990
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