Maternal and fetal leptin level correlation with fetal macrosomia

ABSTRACT

Leptin seems to be a critical factor for overall fetal development. Macrosomia may place the mother and fetus or neonate at risk for adverse outcomes. To test if leptin level is implicated in macrosomia. The sample comprised 25 cases delivered full term normal weight infants, and 25 cases delivered full term macrosomicinfants. Maternal serum samples and fetal cord samples were withdrawn immediately after birth of the full term infants. Fetal leptin level was higher in macrosomic infants than normal weight infants. No difference in maternal leptin level between both groups was observed. Leptin levels related directly to quantity of body fat tissue in fetal macrosomia as there is leptinresistence causing elevated leptin levels