seroprevalence of campylobacter jejuni in patients with irritable bowel syndrome and in healthy individuals

ABSTRACT

The patients with Post-Infectious Irritable bowel syndrome [PI-IBS], a subtype of irritable bowel syndrome, suffer from bacterial gastroenteritis. Since Campylobacter Jejuni [C] is one of the most common agents in this syndrome, we aimed to evaluate the prevalence of Campylobacter Jejuni in patients with Irritable Bowel Disease. This case - control study was conducted on 160 patients divided into 2 equal groups of healthy and unhealthy. The presence of Anti- CJ antibody [IgG and IgA] was evaluated by ELISA and the comparison was performed by chi-square test, The mean age of case [31.51] and control [31.84] was not statistically different [P = 0.87]. Titer of Anti- Campylobacter Jejuni antibody IgG was positive in 25% of patients and 18.8% of the healthy ones [p=0.02]. IgA Seropositivity in patients was 7.5% but no one in control group was positive [p =0.01]. The Seroprevalence of CJ in patients with IBS was higher significantly than that of control group. Thus, CJ can be known as one of the causes of Post-infection in patients with IBS in our region and it should be paid more attention in diagnostic assessment of these patients