Human parvovirus B19 infection in females with recurrent spontaneous abortions

ABSTRACT

Human parvovirus B19 is a small DNA virus that is transmitted mainly through contact with respiratory secretion or aerosols, but it may be transmitted to the fetus transplacentally from infected mother leading to many complications mainly fetal hydrops, intrauterine fetal death or spontaneous abortion. In this study we aimed at assessment of the relation between maternal human parvovirus B19 infection and recurrent spontaneous abortion [RSA] and comparing the serological diagnostic methods and PCR for diagnosis of B19 infection in females with RSA. Sera were collected from 50 patients with RSA [patients group] and 25 pregnant females without history of abortion [control group] and all sera were tested by nested PCR to detect B19 DNA and by EIA to detect B19 Ig M and Ig G. 19 DNA was detected in 58% in the patients group and in 4% in control group while B19 Ig M was positive in 6% of the patients group and 4% in the control group but B19 Ig G was positive in 62% and 8% of the patients and control groups respectively