Histomorphological analysis of oral white lesions

ABSTRACT

To histomorphologically analyze the oral white lesions. Descriptive, cross-sectional study. Department of Histopathology, Armed Forces Institute of Pathology [AFIP], Rawalpindi. From May 2011 to May 2012. A total of 54 patients presenting with oral white lesions were included. Age, gender, site and size was recorded. The biopsy sample was fixed in 10% formalin and after standardized processing, slides were prepared, stained by Hematoxyline and Eosin, with special stains when required. The histopathological diagnosis of lesion was recorded. Mean and standard deviation were calculated for quantitative variable. Frequency and percentages were calculated for qualitative variables. Out of total 54 patients 28 were male and 26 females. The age range was 17-80 years with mean age 49.70 years. Majority of the patients were between 50-60 years. Buccal mucosa was affected in majority of the cases [63%], followed by lip mucosa and tongue. Histologically Lichen Planus was the most common lesions [33%], followed by non specific inflammation [14.8%], keratosis without dysplasia [11%], keratosis with dysplasia [7.4%], Pemphigus Vulgaris [6%] and Squamous cell carcinoma [1%].Lichen Planus is the most common cause of white lesion in our set up. Biopsy of an intact epithelial lesion should be considered if the lesion does not resolve in due course of time