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Hepatoprotective effects of curcuma longa against carbon tetrachloride induced liver injury in rats
Medical Forum Monthly. 2014; 25 (1): 2-5
in English | IMEMR | ID: emr-161253
ABSTRACT
To investigate the protective effect of Curcuma longa [CL] against carbon tetrachloride [CC1[4]] induced liver injury in adult male Wistar rat model. Study Experimental/Analytical study Place and Duration of Study Animal House, Isra University Hyderabad from March to December 2013. Forty five adult male Wistar rats were divided into three groups; Group 1. controls received 0.9% isotonic saline, Group 2. received CC1[4] orally [1.9mg/kg] mixed in olive oil, and Group 3. received the CC1[4]+CL [250mg/kg] Blood samples were collected for liver biochemical assays. The animals were sacrificed, liver tissue, after fixation in 4% formaldehyde, was embedded in paraffin. Tissue sections of 5 micro thickness were subjected to haematoxylin and eosin staining and were assessed by light microscopy. The data was analyzed on SPSS 21.0 using one-way ANOVA, Fischer's LSD and Chi-square tests. A p-value of liver biochemical and histological findings reveal statistically significant differences among the controls, CC1[4] and CC1[4]+CL groups [p=0.0001]. Liver enzymes and histology were deranged significantly in CC1[4], group compared to controls and CC1[4] +CL group [p=0.0001]. The CC1[4]+CL group showed less elevation of liver enzymes and derangement in liver histology compared to CC1[4] group [p=0.001]. The histological findings of congestion, inflammatory cell infiltrate, vacuolar degeneration and necrosis are found prominent in CC1[4] group.

Conclusion:

The Curcuma longa protects against oxidative damages caused by carbon tetrachloride induced liver injury in rat mode
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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Med. Forum Mon. Year: 2014

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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Med. Forum Mon. Year: 2014