Effect of insulin and/or oral hypoglycemic drugs on the oxygen consumption of brain in diabetic rats

ABSTRACT

Eighty adult male albino rats of local strains with average weight of 220 gm were used to investigate the effect of insulin and /or oral hypoglycemic drugs on the O2 consumption of brain in diabetic rats. It was found that glibenclamide and insulin, alone and in combination, improved the brain O2 consumption. On the other h and, Metformin decreased the O2 consumption of the brain and decreased the increasing O2 consumption caused by both glibenclamide and insulin possibly by stimulating the anaerobic glycolysis of the cells