Absence of association between -1131T>C polymorphism in the apolipoprotein apoa5 gene and pediatric metabolic syndrome

ABSTRACT

In the present study, we evaluated the association of rs662799 variant of the APOA5gene with Metabolic syndrome [MetS] in a sample of children and adolescents from Isfahan. This case control study comprised 50 cases of MetS and 50 controls. Mismatched polymerase chain reaction-restriction fragment length polymorphism [mPCR-RFLP] was used to genotype -1131T>C polymorphism. No significant association was documented for APOA 5 genotypes with the measured laboratory parameters for CC, CT, and TT genotypes in the two groups studied. By logistic regression using a dominant model, the odds ratio [95% confidence interval 10 for the MetS was 0.38 [0.139-1.0350 and 0.29 [0.08-1.071 for the unadjusted and adjusted models, respectively. This study suggests that among studied children and adolescents, -1131T>C polymorphism in the APOA5gene may not be a major contributor to the MetS risk