Rocuronium bromide: a pharmacological study
Egyptian Journal of Hospital Medicine [The]. 2001; 2 (March): 1-10
in English
| IMEMR
| ID: emr-162050
ABSTRACT
This work was designed to assess the pharmacological effects of rocuronium. In either isolated preparation or intact animals. Rocuronium [6-96 micro g/ml] caused a significant dose related reduction in the amplitude of rat phrenic nerve diaphragm contraction in response to indirect stimulation, the mean percentage reduction were statistically significant. The addition of neostgmine [0.25 micro g/ml] caused complete reversal of the relaxant effect of rocuronium . In intact cat gastrocnemius sciatic nerve preparation rocuronium [25 - 200 micro g/kg] caused dose dependent statiscally significant reduction. In comparing the drug with succinyl choline by the head drop method the mean time in second was 15.34 +/-1.57 and 10.44 +/-0.91 respectively
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phrenic Nerve
/
Rats
/
Sciatic Nerve
/
Cats
/
Neostigmine
Limits:
Animals
Language:
English
Journal:
Egypt. J. Hosp. Med.
Year:
2001
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