protective role of royal jelly against sodium nitrate and sun-set yellow toxcity in albino rats

ABSTRACT

In last few years, all over the world, food preservatives and favorable food colour are used in wide scale. However, their use in food still controversial. It causes and will cause severe tension to the consumers as the sensitivity of people to general health increases. This work was carried out to study the possible toxic effect of the interaction of one of food preservatives [sod. nitrite] and one of the most favorable food colour [sun-set yellow] on rates. To study the effect of this interaction, a mixture of 1/10 of the limited dose of Na No3 and sun-set yellow was daily administered to rats. Other group was supplemented with royal jelly in combination with the mixture to evaluate its possible protective role during the course of experiment. Treatments were continued to 30 days, then half of the animals were sacrificed, the other half was left for 15 days after the last dose without any additional treatment [as a recovery period]. The result can be summarized as follows 1. Administration of sod. nitrite and sun-set yellow produced a significant decrease in percentage of body weigh, W.B.Cs, R.B.Cs, Hb, Hct, inorganic phosphorus, serum protein and serum albumin of rats. 2. A marked increase in respiration rate, serum glucose, T3, T4, calcium, gamma-GT, LDH, CPK, alk. ph., serum cholesterol and [brain, liver and heart cholesterol] was recorded during treatment with the mixture. 3. Insignificant change in organ / b.wt., heart beat, rectal temperature, serum and tissue AST and ALT, serum acid phosphates, tissue proteins, serum and tissue total lipids muscle and kidney cholesterol and serum triglycerides was determined. 4. Administration of royal jelly and to some extent a recovery period ameliorated many hazards produced by using food additives. So, this study threw light on the bad behavior and its hazards of using food additives and food colour in the same time by our kids. It is also clear that royal jelly as a natural product nearly ameliorate these damage. So, it's advisable to administered royal jelly to children and prevent if possible the using of additive and synthetic colour in their food