Antioxidant defense of pycnogenol against glycerol induced acute renal failure in mice
Egyptian Journal of Hospital Medicine [The]. 2009; 34 (March): 1-8
in English
| IMEMR
| ID: emr-162101
ABSTRACT
The present study aims to demonstrate the efficiency of pycnogenol as a protector in male mice against hazards effect in kidney functions induced by glycerol. Mice were received i.m. injection 50% glycerol [8ml/ kg b.wt] 30 minutes prior to glycerol administration, other group received orally pycnogenol [400mg/ kg b.wt] over a period of 12 hours. Lipid peroxidation products [MDA, PC], non-enzymatic and enzymatic antioxidant [GSH, CAT, SOD] were estimated, in addition serum protein, urea, createnine concentration as well as serum Na, K levels were determined. It seems that rhabdomyolysis effect caused by glycerol can be controlled to some extent by pycnogenol administration
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rhabdomyolysis
/
Urea
/
Lipid Peroxidation
/
Creatinine
/
Acute Kidney Injury
/
Glycerol
/
Mice
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Egypt. J. Hosp. Med.
Year:
2009
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