added value of advanced neuro-imaging [MR diffusion, perfusion and proton spectroscopy] in diagnosis of primary CNS lymphoma

ABSTRACT

Primary CNS lymphoma is difficult to diagnose with conventional imaging modalities. Magnetic resonance proton spectroscopy, dynamic susceptibility contrast DSC perfusion and diffusion weighted images have been recently investigated as a problem-solving tool for evaluation of primary CNS lymphoma with favorable results. To assess the value of advanced neuro-imaging [MR diffusion, perfusion and proton spectroscopy] in diagnosis of primary CNS lymphoma. Five adult patients with suspected primary CNS lymphoma [as suggested by clinical or conventional imaging techniques] were prospectively studied by magnetic resonance proton spectroscopy, dynamic susceptibility contrast DSC perfusion and diffusion weighted images aiming to confirm the suspected diagnosis. The examinations were done on 1.5T machines using diffusion weighted, dynamic susceptibility contrast perfusion and chemical shift CSI imaging sequences. Regarding DWI, all patients show low ADC value of 0.63 +/- 0.025[SD] x 10[-3] mm[2]/s, regarding the DSC perfusion. The max rCBV ratios are ranging from 0.23 to 1.52 with a mean ratio of 1.14 +/- 0.54[SD]. Regarding