Level of resistin in acute myocardial infarction patients and its relation to lipid profile and cardic troponin I

ABSTRACT

Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Myocardial Infarction [MI] is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI. To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acute myocardial infarction patients. The study included 50 patients with AMI and forty healthy subjects as control group. In this study resistin, lipid profile and Troponin I were measured. The levels of resistin, cholesterol, LDL-C were significantly elevated with [p<0.001], while HDL-C was significantly lower with [p<0.001], there was positive correlation between resistin with cholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation between resistin with HDL in acute myocardial infarction. There was a significant increase in resistin level, in acute myocardial infarction patients and this increase may be related to inflammation. Resistin negatively correlated with HDL and positively correlated with triglyceride and LDL this relationship makes us consider this hormone as possible atherosclerotic factor