association between adiponectin with lipid profile and troponin in acute myocardial infarction patients

ABSTRACT

Adiponectin is thought to be exclusively synthesized by adipocytes; however, a recent suggestion stated that adiponectin is also synthesized and secreted by human cardiomyocytes. Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity. So obesity consider the major independent risk factor for atherosclerotic cardiovascular disease Acute Myocardial Infarction [AMI], is the interruption of blood supply to part of the heart, causing some heart cells to die. Insulin is a very important hormone as it regulates the level of glucose, in the blood. Troponin is a complex of three regulatory proteins that is integral to muscle contraction in skeletal and cardiac muscle. To monitor adiponectin level and its effect on lipid profile and Troponin levels in Acute Myocardial infarction patients. The study included 50 patients with Acute Myocardial infarction and forty healthy subject as control group. This study designed to measure adiponectin, lipid profile and troponin levels. Levels of adiponectin, cholesterol, LDL-C and Troponin were significantly elevated with [p<0.001], while HDL-C was significantly lower with [p<0.001], There was negative correlation between adiponectin with, cholesterol LDL-C, triglyceride and VLDL, and there was positive correlation between adiponectin with HDL in acute myocardial infarction. The significant increase in adiponectin in AMI may be related to inflammation. From the relation of adiponectin with lipid profile, adiponectin can increase level of HDL and decrease level of triglyceride so this suggested that adiponection have anti-atherosclerosis properties