seroprevalence of IgM among Iraqi aborted women infected with human cytomegalovirus

ABSTRACT

Fetal loss and abortion are responsible for significant emotional distress for couples desiring children. There are many documents which support the role of some certain asymptomatic infections such as Cytomegalovirus [CMV] in spontaneous abortion. This study was aimed to evaluate the prevalence of seropositivity of specific IgM antibody for CMV by ELISA in the sera of [108] women with recurrent abortion associated with obstetric complications. This study was carried out in two central hospital in Baghdad [Al-Elwea and Baghdad teaching hospitals] during [2009-2010]. A number of [108] women with definite diagnosis of previous abortion, 35women with recurrent abortion, 30 women with premature delivary and 43women with intra uterine death.compered to [50] women with history of normal full term delivary and negative history of miscarrage as control groups.Serum samples were collected and then tested by using ELISA for detection of anti-CMV IgM antibodies. Cytomegalovirus [CMV] specific IgM antibody was detected in [15.7%] of the 108 women studied, while the women with obstetric complications were positive for CMV specific IgM antibody these comprised of [16.6%] with premature delivary ,[14%] with recurrent abortion and [16.2%] with intra uterine death. these result statistically significant [P<0.05].Our data faild to found asignificant association between the Cytomegalovirus infection with age and residence of patients [p>0.01]. Higher seropositivity for cytomegalovirus [CMV] in women with spontaneous abortion compared to women with normal obstetric history suggests that cytomegalo virus Plays a sigificant role in abortion