Prevention and non-invasive therapy of gastrointestinal disorders: saving lives by a science based approach to NSAIDs
EMJ-Emirates Medical Journal. 2006; 24 (1): 13-19
in English
| IMEMR
| ID: emr-163217
ABSTRACT
During the last 15 years management of patients who need to take non-steroidal anti-inflammatory drugs [NSAIDs] has been revolutionized by the availability or co-prescription of prostaglandin analogues such as misoprostol or proton pump inhibitors and by the emergence of selective inhibitors of the inducible cyclo-oxygenase [COX]-2 enzyme. This paper describes work mainly from the Division of Gastroenterology [now Wolfson Digestive Diseases Centre], that investigated numerous strategies in acute and/or explanatory studies before evaluating their effectiveness in large patient studies with endoscopy or clinical outcome as an endpoint The data show, contrary to common pre-conception, that acute changes are highly predictive of patient outcomes. It seems likely that some strategies that were never evaluated in patient studies would he effective
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Emirates Med. J.
Year:
2006
Similar
MEDLINE
...
LILACS
LIS