Monoclonal antibodies: an evaluation in routine blood group serology

ABSTRACT

The monoclonal anti-A, anti-B, and anti-AB were evaluated in parallel with conventional human antisera to test their suitability as routine blood grouping reagents in the present working conditions of the Central Blood Bank, Salmaniya Medical Centre. The tests for specificity, avidity, antibody titre and firmness of agglutination were carried out. The monoclonal antibodies performed well compared to the human antisera and produced a distinct agglutination in slide and tube method. Monoclonal antibodies can be used safely in routine blood group serology and in various disease conditions. They appear to be cost effective in the long run