Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice

ABSTRACT

Background: Postpartum depression [PPD] affects approximately half of new mothers. Chronic exposure to progesterone during pregnancy and its withdrawal following delivery increases depression and anxiety. In addition, there are complex interactions between hormones, neurotransmitters, and trace elements. Zinc [Zn] and magnesium [Mg] in Auence the nervous system by impacting synaptic neurotransmis-sion in the brain. Thiamine [Vit B[1]] deficiency results in a high percentage of depressive behaviors. Elevated levels of reactive oxygen species in pregnancy are implicated in the pathogenesis of major depression