Effect of Allium Cepa on blood Glucose levels of normal and Alloxan treated Diabetic rabbits

ABSTRACT

The aquous solution of dried powder of the Allium cepa was administered in doses of 100, 150 and 200 mg/kg body weight to normal and alloxan treated diabetic rabbits. The blood glucose levels were estimated before and 2,4,6 and 8 hours after the administration of the solution. The solution exerted a significant [P< 0.05] hypoglycaemic effect in both normal and diabetic rabbits. In normal rabbits, oral administration of 150 and 200 mg/kg doses caused decrease in blood glucose levels at 2,4,6 and 8 hours, while maximum decrease was at 6 hours. In the alloxan treated diabetic rabbits, 200 mg/kg dose only could produce significant decrease at 4,6 and 8 hours while maximum decrease was at 6 hours. The doses used did not show acute toxicity or behavioral changes. It may be concluded that the plant contains one or more hypolglycaemic principles which can reduce the blood glucose in normal rabbits and in those with alloxan induced diabetes