[Evaluation of knocking down of the RNAi mediated gamma globin repressor into K562 cells, for gene therapy of beta-thalassemia]
Pejouhandeh: Bimonthly Research Journal. 2011; 16 (5): 234-240
in Persian
| IMEMR
| ID: emr-163624
ABSTRACT
Background and Aim:
Beta-thalassemia is a genetic disorder manifested by the presence of anemia in adult patients. One approach to treatment of beta-thalassemia is induction of the fetal gamma-globin gene. One of the gamma-globin repressors is a complex called DRED [Direct repeat erythroid-definitive]. DRED is composed of TR2 and TR4 DNA binding subunits. The aim of this study was to set up the RNAi system to increase the expression of the gamma-globin gene
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Repressor Proteins
/
RNA
/
Genetic Therapy
/
Beta-Thalassemia
/
K562 Cells
/
Gamma-Globins
Language:
Persian
Journal:
Pejouhandeh: Bimonthly Res. J.
Year:
2011
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