Arab Journal of Pharmaceutical Sciences. 2012; 4 (8): 139-146
in Arabic
| IMEMR
| ID: emr-163735
ABSTRACT
This method was applied to perform a comparative study of optical purity of some generic solid pharmaceutical products of esomeprazole [capsules, tablets] manufactured locally and in some neighbouring countries for the determination the percentage of R enantiomer. A product of under license company was used for comparison of the results. The study was performed by using a validated HPLC method on chiral column Nucleocel Alpha S and a mixture ethanol hexane [7030, v/v] as a mobile phase, the flow rate was 0.65 ml/min, and the detection was carried out using UV detector at 302nm. The temperature of column was set at 25[degree]C. The study showed that some samples were not polluted with R enantiomer, while the others contained this enantiomer in the range of 0.1-2.24%
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Omeprazole
/
Chemistry, Pharmaceutical
/
Chromatography, High Pressure Liquid
/
Optical Phenomena
Language:
Arabic
Journal:
Arab J. Pharm. Sci.
Year:
2012
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