Association of hypertension and diastolic dysfunction with type-2 diabetes mellitus

ABSTRACT

To evaluate the prevalence of hypertension and diastolic dysfunction [LVDD] with normal ejection fraction in type-2 diabetes mellitus. Two hundred twelve diabetic patients [98 females and 114 males] from January 2005 to June 2006 were enrolled in this study. Their ages ranged from 35 to 65 years with mean age of 55 years. Patients with Diabetes Mellitus Type-2, Hypertension BP[3]140/90 [with or without medication] Body Mass Index[3]30, Waist-Hip ratio>0.90. Left Ventricular Diastolic Dysfunction [LVDD] and Serum Triglyceride and HDL Cholesterol were included. Result: Out of 212 patients, 104[49%] were found to be hypertensive [both systolic and diastolic] and 12 patients [5.6%] were found to be suffering from isolated systolic hypertension. Hence total number of hypertensive patients was 116 [54.6%]. Thirty two patients were found to be suffering from diastolic dysfunction. Hypertension and Diabetes are interlinked and show how micro and macrovascular complications of diabetes are increased when two conditions occur together. The LVDD is much more prevalent than previously suggested in patients with type-2 diabetes mellitus. Hence LVDD is an early marker of diabetic cardiomyopathy