Prevalence of antibiotic resistance among bacteria isolates of lower respiratory tract infection in copd Shahrekord, Iran, 2005

Bacterial infection is one of the several important causes of exacerbations of chronic obstructive pulmonary disease [COPD]. Antibiotic resistance has increased in all the major pathogens. The objective of this study was investigate frequency of drug resistance of species from LRTs. This cross sectional study was performed in Hajar hospital of shahrekord-Iran. Protected brush samples were obtained from the lower respiratory tract by bronchoscopy in both hospitalized and ambulatory 54 COPD patients with exacerbations yield. The in vitro susceptibilities of the isolates to 6 antimicrobial agents were then determined by the broth microdilution test. Among the s. pneumonia isolates tested 5.9% and 94.1% were intermediate and high level resistant to penicillin and ampicillin respectively. 58.8% of isolates were erythromycin resistance. H.influenzae isolates were 100% resistance to penicillin and ampicillin. Antibiotics are an important part of the treatment of COPD, suggesting that every effort should be made to conserve sensitivity of antibiotic by using them appropriately