Significance of D-dimers in newborns to pre-eclamptic mothers

ABSTRACT

The objective of the study was to compare the concentration of D-dimer in cord blood of neonates born to pre-eclamptic mothers with the cord blood of full term neonates born to healthy mothers. The concentration of D-dimer was assayed by using latex agglutination and semi-quantitative determination of D-dimer in plasma by kit of Stago Diagnostics France. Lady Wallingdon Hospital Lahore. Duration of study January 2003 to September 2003. The concentration of D-dimer was significantly raised in both pre-term and full term index group as compaxed to the control group However, the concentration of D-dimer was higher in gestational age group 28[th] to 31[st] weeks due to the prematurity. The increased concentration of D-dimer indicates the activation of fibrinolytic system and make it mandatory to observe the neonates up to forty-eight hours so that the hemorrhagic disease of the neonate can be predicted and managed accordingly