Anti-inflammatory and anti-microbial activity of zuroor-e-gaozaban a polyherbal unani formulation

ABSTRACT

Zuroor-e-gaozaban is a polyherbal Unani formulation, traditionally used as a local application for treating oral white stomatitis/white thrush and traditionally known to be having antiseptic action. The formulation was screened for anti-inflammatory activity and in vitro antimicrobial activity. Aqueous suspension of the formulation was screened for in vivo anti-inflammatory activity, at dose levels of 100, 200, 400 mg/kg, using the carrageenan induced rat paw oedema test. The formulation showed a very mild anti-inflammatory activity; the results were compared with standard anti-inflammatory drug, indomethacin 20 mg/kg orally. The extracts and suspensions prepared from the formulation were screened for antimicrobial activity using agar well diffusion method, against standard strains of two bacteria, Staphylococcus aureus and E. coli, and a strain of fungus Candida albicans. The extracts and suspensions were not found effective against both the standard bacterial strains and the strain of fungus. The results were compared with the results obtained using standard antibiotics, vancomycin, and amikacin discs