[ comparison study between the release of mebeverin hydrochloride from tablets using hydrophilic and insoluble polymers]

ABSTRACT

Polymers play an important role in the drug release from solid dosage forms, and this importance varies as the kind of polymer and its percentage in the formulation. In this research we reveal the role of hydrophilic polymers or insoluble polymers in the release of mebeverine hydrochloride from sustained release tablets. HPMC15000 had a great effect in controlling the release of mebeverine hydrochloride from tablet after it had been used at rate of 15% in the inner phase, where the release rate of mebeverine hydrochloride reached 70% during 12 hours, and 86% after 24 hours, and when increasing the dose of mebeverine hydrochloride from 200 mg per tablet to 300 mg, it was necessary to increase the rate of HPMC15000 up to 17,5% and the average release was 62% during 12 hours and 86% after 24 hours. But when using neutral polymers of acrylic acid derivatives [Eudragit RL and RSI there were noticed differences in the release rate of mebeverine hydrochloride from the prepared tablets, and that was according to the type of Eudragit used and the rate of hydrophilic groups in it, Eudragit RL caused a total release of mebeverine hydrochloride from tablet after only 8 hours, and a combination of Eudragit RS and RL [3/1] released 90% of mebeverine hydrochloride during 24 hours, while Eudragit RS alone released 80% of this drug