Experimental study of a non-pharmacopoeal formulation with reference to its chronic anti-inflammatory activity

ABSTRACT

This study presents the chronic anti-inflammatory effect of a non-pharmacopocal Unani formulation. Both the aqueous and alcoholic extracts were tested for chronic anti-inflammatory activity by cotton pellet implant test. Since, most of the mainstream anti-inflammatory medicines have significant gastric toxicity, therefore the test combination was subjected to the test for ulcerogenic activity. For comparison of anti-inflammatory and ulcerogenic activities the standard drug Piroxicam was used. The LD50 was also performed to find out the safety margin of test drug. The test drug showed significant anti-inflammatory activity against chronic inflammation. The test combination also exhibited gastro-friendly effect and the safety margin was found very very large. Both the extracts have shown significant activity but aqueous extract was found more effective