Regulation of ROS defense system by Hybanthm enneaspermus in CC1[4] induce cardiac damage
Pakistan Journal of Pharmaceutical Sciences. 2015; 28 (4): 1397-1399
in English
| IMEMR
| ID: emr-165783
ABSTRACT
The purpose of this study is to regulate the ROS [Reactive oxygen species] defense system in cardiac damage induced by CCI[4] [Carbon tetra chloride] in rats using Hybanthus enneaspermus. Administration of CC14 induces damage in the heart of rats as proved by estimation of antioxidant enzymes such as, SOD [Superoxide dismutase], CAT [catalase], GPx [Glutathione Peroxdiase], GR [Glutathione Reductase], GST [Glutathione-S-Transferaes]. However, treatment with HEE in CCI[4] intoxicated rats was found to be protected the heart, as indicated by the enzyme level in serum. A significant increment of serum enzymes level such as SOD, CAT, GPx, GR and GST were observed following HEE treatment during CCI4 intoxication whereas MDA [Malondialdehyde] level in HEE treated rats were decreased. The results of our experiment suggest that the treatment of HEE may be the critical remedy for the adverse effect of CCI[4] in heart function
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2015
Similar
MEDLINE
...
LILACS
LIS