Regulation of ROS defense system by Hybanthm enneaspermus in CC1[4] induce cardiac damage

ABSTRACT

The purpose of this study is to regulate the ROS [Reactive oxygen species] defense system in cardiac damage induced by CCI[4] [Carbon tetra chloride] in rats using Hybanthus enneaspermus. Administration of CC14 induces damage in the heart of rats as proved by estimation of antioxidant enzymes such as, SOD [Superoxide dismutase], CAT [catalase], GPx [Glutathione Peroxdiase], GR [Glutathione Reductase], GST [Glutathione-S-Transferaes]. However, treatment with HEE in CCI[4] intoxicated rats was found to be protected the heart, as indicated by the enzyme level in serum. A significant increment of serum enzymes level such as SOD, CAT, GPx, GR and GST were observed following HEE treatment during CCI4 intoxication whereas MDA [Malondialdehyde] level in HEE treated rats were decreased. The results of our experiment suggest that the treatment of HEE may be the critical remedy for the adverse effect of CCI[4] in heart function