New treatment of hyperemesis gravid arum a randomized study

ABSTRACT

A randomized study was undertaken to assess efficacy of micronizedprogesterone as a new treatment ofhyperemesis gravidarum compared with anti-emetics, anti-histaminics, liver support, vitamin B6 and intravenousfluids.The study was conducted on 40 pregnant ladies diagnosed as hyperemesis gravidarum. They wererandomized into 2 groupsGroup [I] includes twenty cases where intravenous fluids [5-6 L], sodium bicarbonate, liver support, vitamin B6,anti-emetics and anti-histaminics were given.Group [II] includes twenty cases were treated with micronized progesterone, intravenous fluids and sodiumbicarbonate were given.Both groups were subjected to complete blood picture [CBP], liver and kidney function tests, serum sodium [Na] and potassium [K], serum estrogen and progesterone estimations.This study indicated that significant differences were found on both groups between CBP, liver and kidneyfunction tests, serum Na and K levels, serum estrogen and progesterone levels after treatment than before.Signiflcnt differences were found between the two groups after treatment as regard kidney and liver function testsand also, seum progesterone levels.Intavenous fluid hydration and electrolytes correction is essential in the management of hyperemesisgravidarum. Micronized progesterone is an effective therapy as anti-emetics, anti histaminics, vitamin B6 and liversupport in controlling hyperemesis gravidarum