comparative study of different methods of insulin administration on blood glucose, serum phosphate and potassium in diabetic rabbits

ABSTRACT

A study employing different methods of insulin administration was done to compare their effects on blood glucose, serum phosphate and potassium levels in altoxan-diabetic rabbits [ALX-D]. Maximum reduction in blood glucose level occurred in 1,2,3, and 4h after intravenous [lV] intraperitoneal [IP], subcutaneous [SC], or eye drops methods, respectively. The maximum reduction in serum phosphate and potassium levels occurred at 1,2h after IV, IP, respectively, and 3h after SC and eye drops methods. The recovery to original normal values was also quicker with IV or IP methods than SC or eye drops methods of administration. It was interesting to note that the magnitude of insulin action did not significantly differ between SC and eye drops method and was comparable to IP or IV methods of administration