Predictive value of phosphorylated insulin-like growth factor binding protein-1 [PIGFBP-1] [bedside test] in preterm labor

ABSTRACT

This study evaluated the predictive value of phosphorylated insulin like growth factor binding protein-1 in cervical secretion as bedside test for prediction of preterm labor in symptomatic women.A total of 57 patients with singleton pregnancy at 24-34 weeks gestation, with symptoms suggestive of preterm labor were included in this study. A rapid cervical sample for PIGFBP-1 determination [Actim partus test, Medix Biochemical, and Kaunianen, Finland] was taken by means of a polyester-tipped swab during a speculum examination of the cervix, and extracted with specimen- extraction solution. We analyzed the prevalence of preterm labor in these patients within seven days upon admission. And calculate sensitivity, specificity, positive predictive value [PPV] and negative predictive value [NPV] for PIGFBP-1. This study was done at Kuwait Oil Company hospital [KOC] and Taiba hospital [Kuwait] during the period between April 2011 and June 2012.The test was positive in 50.9% of patients and negative in 49.1%, among those tests was positive 64% delivered less than a week, and among those tests was negative 35.7 delivered less than one week, with 74.3% sensitivity, 61% spesivity, 76.3% PPV and 73.6% NPV