Risk factors of endometrial polyps in tamoxifen treated postmenopausal breast cancer patients

ABSTRACT

Endometrial polyps are the most common endometrial pathology associated with postmenpausal tamoxifen exposure. Up to 3% of these polyp may show malignant changes. is the endometrial cancer has predisposition or risk factors in postmenpausal tamoxifen receiving breast cancer patients risk factors for endometrial polyps. This is prospective study done at El-Hussien and Sayed Galal University hospitals the data were collected from medical records after the patient consent to be involved in this study we have two groups group I in which the hystrescope reveals the endometrial polyp at 6 months of tamoxifen receiving in postmenopausal breast carcinoma patients. Group II in which the hystrescope reveals nothing each group has 20 patients and follow up for one year. age at menopause was significantly older, increased duration of breast disease increased body weight, increased endometrial thickness. In group I if these compared by group II. Various factors such as old age at menopause, increased duration of breast disease increased body weight. Thicker endometri urn may contri bute to the prediction of increased risk of development of endometrial polyp in postmenopausal patients with breast carcinoma treated by tamoxifen