Effect of flaxseed on reduction of diabetic complications in experimental rats

ABSTRACT

This work is aimed to study the effect of feeding flaxseed in management of Diabetes mellitus in experimental rat. About Thirty five male albino rats were used, experimental diabetes was induced. Rats were classified in groups as control, diabetic, diabetic received 5, 10 or 20% of flaxseed in the diet. After 6 weeks blood samples were collected also, the right femur was removed. Glucose concentration of diabetic rats treated with 5%, 10% or 20% flaxseed was significantly decreased. Upon adding flaxseed at 5, 10 or 20% ratios treatment in diabetic rats, kidney function mean values were normalized. ALT, AST, TC, TG, LDL-c and VLDL-c were increased in diabetic group; the level was decreased as rats received flaxseed. Bone mineral density and content in diabetic group were reduced and normalized after receiving flaxseed. So, diabetes has more pronounced effect on serum glucose, liver, and kidney functions lipids profile, and bone health and flaxseed has beneficial effect on the prevention of osteoporosis