To observe the effects of metformin hc1 on the carbohydrate metabolism in polycystic ovary syndrome

ABSTRACT

To observe the effects of metformin HC1 on the carbohydrate metabolism in polycystic ovary syndrome a clinical trial was carried out on fifty infertile females having polycystic ovary syndrome with ages between 20-40 years. They were enrolled from the infertility clinic of a private hospital in Karachi and were given tablet metformin HC1 500 mg thrice daily for a period of three months. Fasting serum glucose [FSG] and fasting serum insulin [FSI] were done twice during the study period [at day zero and day ninety] to assess the effects on the carbohydrate metabolism. Significant reduction was found in both the FSG and FSI levels at day ninety with P=0.001. It is concluded that metformin has produced beneficial effects on the carbohydrate metabolism in patients having polycystic ovary syndrome. This is because of increase peripheral uptake and utilization of glucose being done by metformin which in turn increases the insulin sensitivity and reduces the insulin resistance in these patients