Iranian Journal of Veterinary Research. 2014; 15 (4): 392-396
in English
| IMEMR
| ID: emr-166510
ABSTRACT
A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone [CoQ10] on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups [n=20]. Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group [P<0.05]. Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group [P<0.05] Intraperitoneal administration of CoQ10 [10 mg/kg/day] in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Sciatic Nerve
/
Rats, Wistar
/
Nerve Regeneration
Limits:
Animals
Language:
English
Journal:
Iran. J. Vet. Res.
Year:
2014
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