Cardiovascular and renal protection in type 2 diabetic hypertensive patients. the role of calcium channel blockers
Medical Forum Monthly. 2015; 26 (5): 5-8
in English
| IMEMR
| ID: emr-166545
ABSTRACT
To study the effects of Calcium Channel Blocker [Amlodipine] as monotherapy in diagnosed hypertensive, non-insulin dependent diabetes mellitus [NIDDM] patients. Prospective study. This study was conducted at Jinnah post graduate medical centre [JPMC] Karachi, in collaboration with the department of medicine JPMC, Karachi from July 2010 to January 2011. This study is to examine the effects of Amlodipine in type 2 diabetic hypertensive patients with base line proteinuria. 20 normal subjects were also selected as a control group with CCB [Amlodipine] baseline to final change for SBP as well as DBP was significantly reduced i.e.24.70 % [p<0.001] and 16.20% [p<0.001] respectively. CCB showed 44% [p<0.001] reduction in FBS, creatinine clearance reduced by 8.10% [p<0.5], serum potassium reduced by 4.50%, non significant increase in serum urea i.e.3.70% and serum creatinine i.e. 3.8% was observed. Aim of treating hypertension is to control or limit its cardiovascular complications; CCB and are the drug of choice in controlling blood pressure and to prevent the progress of cardiovascular events in patients without diabetic nephropathy as well as reserves for add-on therapy in hypertensive patients complicated with diabetic nephropathy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Cardiovascular System
/
Prospective Studies
/
Amlodipine
/
Diabetes Mellitus, Type 2
/
Hypertension
/
Kidney
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. Forum Mon.
Year:
2015
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