Amelioratory effects of vitamin E against biochemical toxicity induced by deltamethrin in male rats

ABSTRACT

Deltamethrin [DLM] is a synthetic pyrethroid insecticide known for its wide toxic manifestations. The present experiment pertains to the protective role of vitamin E [vit E] against biochemical toxicity following pesticide exposure during 30 days. Male albino rats were divided into four groups of six each Group I served as control rats [0 mg [vit E] and 0 mg DLM/kg body weight], Group II received deltamethrin [7.5mg/kg body weight]. Group III received vit E [100 mg/kg body weight]. Group IV received both deltamethrin [7.5mg/kg body weight] plus vit E [100mg/kg body weight]. Exposure of rats to DLM induced significant increase in the levels of hepatic markers enzymes, alanine aminotransferase [ALT], aspartate aminotransferase [AST], and alkaline phosphatase [ALP]; while acetylcholinesterase [AChE] was inhibited. Significant decrease in catalase [CAT] and glutathione S-transferase [GST] enzyme activities were observed in treated rats. Furthermore, renal markers such as urea and creatinine were increased in deltamethrin treated rats. Additionally, serum cholesterol, triglycerides, low-density lipoprotein [LDL] and the level of high-density lipoprotein [HDL] were significantly increased and decreased, respectively. Co-administration of vit E restored all the parameters cited above to near-normal values. Our investigation showed that vit E acts as an effective antioxidant for DLM pesticide toxicity in reducing oxidative stress burden