Cytokines [interleukin-10 and interferon-gamma] associated with non hodgkin's lymphoma

ABSTRACT

Cytokines are small soluble peptides used by the immune system to communicate with and to influence the cellular function. This study was performed in a group of newly diagnosed non Hodgkin's lymphoma [NHL] patients to detect the presence of serum interleukin 10 and interferon-Gamma secreted from T helper 2 [TH2], T helper 1 [TH1] respectively. Thirty-five newly diagnosed non Hodgkin's lymphoma patients were studied immunologically for the detection of serum interleukin-10 [IL-10] and interferon-Gamma [IFN-Gamma] by enzyme immunoassay, the data of whom were compared with 20 healthy donors as a control group. Serum interleukin-10 was detected in 48.5% of non Hodgkin's lymphoma patients compared to none among the healthy controls. While serum interferon-Gamma was detected in only 8.57% of non Hodgkin's lymphoma patients compared to none among the healthy controls. Interleukin-10 in the sera of patients with newly diagnosed non Hodgkin's lymphoma, but id did not precisely reflect disease dissemination or stages. While-interferon-Gamma was detected in a smaller percentage and may be a good prognostic sign. None of the patients had both cytokines at diagnosis