Comparison of analgesic effects of tramaddol and lidocaine in reduction of propofol induced pains

ABSTRACT

Propofol is frequently associated with pain on injection. Numerous methods were introduced to alleviate the pain. This study was designed to assess the effectiveness of Lidocaine compared with tramadol in reducing pain on propofol injection. In a randomized, double blind study, 60 patients were selected for this study and divided into two equal groups of A and B based on receiving tramadol and lidocaine respectively. Following venous occlusion by a pneumatic tourniquet placed on the arm and inflated to 50 mmHg above the baseline systolic pressure, a dose of 50mg [10cc] of tramadol was injected in group A [n= 30] and 50 mg [10cc] of lidocaine in group-B [n=30] and the tourniquet pressure was released after one minute. A dose of 2.5 mg/kg of propofol [20[degree sign] C - 25 [degree] C] was then administered as bolus dose over 30 seconds. Pain assessment was made 30 seconds after the start of the injection. There was a significant reduction in the incidence of propofol-induced pain when administered in both groups. The incidence of pain was 13.34% in group-A as compared to 16.66% in group-B without any significant difference. Pretreatment with tramadol is an effective as lidocaine in reducing pain on propofol injection