Clinical investigation of hypoglycemic effect of leaves of Mangifera inidca in type-2 [NIDDM] diabetes mellitus

ABSTRACT

The present study was designed to investigate clinically the hypoglycemic effect of leaves of Mangifera indica in Type-2 diabetes mellitus. After assaying fasting plasma and urinary glucose, 10 patients of type-2 diabetes mellitus with no previous medicaion, 10 patients of type-2 diabetes mellitus taking oral hypoglycemic agents with history of inadequate control and six control subjects were given low [0.5 g/kg/d in two divide doses] and high [1 g/kg/d in two divided doses] doses of powdered part, aqueous extract and alcoholic extract of leaves of Mangifera indica for 14 days. On 15[th] day blood and urine samples for glucose were taken. Based on results obtained it was found that Mangifera indica has significant hypoglycemic activity in high dose and can be successfully combined with oral hypoglycemic agents in type-2 diabetic patients whose diabetes is not controlled by these agents