[Effects of niasine on serum phosphorus, PTH and lipid profile in the hemodialysis patients in Shahroud city]

ABSTRACT

Control of the phosphorus, parathyroid hormone, and serum lipids in dialysis' patients is very important and can be done in many ways. The purpose of the study was to determine the effect of niacin on the serum phosphorus, parathyroid hormone and lipid profile among hemodialysis patients. This double blind controlled randomized study was done on 120 dialysis patients whom were divided into two groups 60 patients [taking niacin] and 60 patients as control groups [taking placebo]. Niacin was prescribed as increasing dose from 200 mg to 600 mg monthly in three steps. Phosphorus, PTH and lipid profile were measured in the both groups. P-value<0.05 was considered as significant. 40 patients of case group [66.7%] and 37 patients [61.7%] of control group were male. Niacin significantly decreased serum levels of phosphorus [p<0.001] and parathyroid hormone [PTH] [p<0.001], also it significantly increased serum levels of HDL [p<0.01]. Nicotinic acid can decrease serum phosphorous and PTH level, and increase HDL cholesterol level. However, it needs a well design and larger trial study for determining the most effective doses of the nicotinic acid