Effect of vitamin E and metformin on fatty liver disease in obese children- randomized clinical trial
Iranian Journal of Public Health. 2014; 43 (10): 1417-1423
in English
| IMEMR
| ID: emr-167620
ABSTRACT
We evaluated the effect of vitamin E and metformin on fatty liver disease in obese children. This interventional study has been done on 119 children with Non-alcoholic fatty liver disease [based on sonography results]. Patients were divided into four treatment groups; they received metformin 1gr daily [age< 12 years], metformin 1.5 gr daily [age> 12 years], vitamin E 800 U daily and vitamin E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials [IRCT], No.IRCT2013021012421N1 The study group comprised 119 individuals [62 females, 57 males]. The mean age was 10 +/- 3.19 yr. There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients [55.46%], 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received vitamin E 800 u daily [48.1%] and the least therapeutic response was in the group which received vitamin E 400 u daily [14.3%]. After four months, the greater response was seen in vitamin E 400 u daily group [45.8%] and the least response in the metformin 1 gram daily group [19%]. In comparison with metformin, vitamin E is more influential in remission; however both are efficient in treatment of fatty liver. Vitamin E 400 u daily responses better in four-month treatment
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Vitamin E
/
Child
/
Metformin
/
Obesity
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Iran. J. Public Health
Year:
2014
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