[Utility of biochemical markers of bone turnover in diagnosis of osteoporosis and fracture risk prediction]

ABSTRACT

Currently, for the diagnosis of osteoporosis, we search risk factors and measure bone mineral density [BMD] by DXA. However, bone turnover markers, unused still in practice, have shown an interest especially in the prediction of fracture risk. To determine the relationship between bone markers, BMD and osteoporotic fracture. Prospective study of 65 women referred for measure of BMD during the period between May and August 2010. Each patient had a dosage of serum bone formation markers osteocalcin [OC] and N-terminal propeptide of type I collagen [P1NP] and bone resorption markers serum and urinary C-terminal telopeptide of type I collagen [beta-CTX or CrossLaps] as well as parathyroid hormone and calcium. Risk factors of osteoporosis were identified in each case. Our 65 women had a mean age of 58.6 +/- 12.1 years. The majority [83%] were menopausal women. Osteoporosis was found in 52%, osteopenia 26% and normal BMD 22% of cases. An increase in bone turnover markers was correlated with menopause [p = 0. 001 for the OC, p = 0.016 for urinary CTX], a low body mass index [p = 0.015 for OC, p = 0.042 for serum CTX] and osteoporosis [p <0.001 for P1NP, p <0.001 for serum and urinary CTX]. Corticosteroid therapy was correlated with a decrease in bone formation markers [p = 0.002 for P1NP]. The presence of fracture was only associated with increased urinary CTX [p = 0.05]. Bone turnover markers increase in menopausal women and in case of low BMD. However, their contribution in the diagnosis of osteoporosis is low. They are rather an interest in the prediction of fracture risk