Voltammetric behavior and determination of trace amounts of omeprazole using an edge-plane pyrolytic graphite electrode

ABSTRACT

The voltammetric performance of edge-plane pyrolytic graphite [EPG] electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole [OMZ] in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit [3 nM] of the electrode response as well as wide linear range [0.01 to 4.0 microM] can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained