IJPR-Iranian Journal of Pharmaceutical Research. 2015; 14 (2): 547-557
in English
| IMEMR
| ID: emr-167961
ABSTRACT
Regarding the therapeutic properties of Nigella sativa [NS], the effects of the plant hydroalcoholic extract on learning, memory and brain tissues oxidative damage were investigated in penthylenetetrazole [PTZ]-induced repeated seizures. There were 4 experimental groups including 1- control group; received saline, 2- PTZ group; received saline and PTZ [50 mg/Kg, i.p], 3- PTZ-NS 200 and 4- PTZ-NS 400 ; received 200 and 400 mg/Kg of NS extract respectively, before PTZ injection in 5 consecutive days. Seizure scores were lower in PTZNS 200 and 400, furthermore the seizure onset latencies were higher in these groups than PTZ group [P<0.05 and P<0.01]. In Morris water maze, the time spent in target quadrant by PTZ group was lower than control group [P<0.05]; while, 400 mg/Kg of the extract increased it [P<0.01]. In the passive avoidance test, delay time to enter the dark by PTZ group was lower than control at 1 and 24 hours after training [P<0.01 - P<0.001]; while, 400 mg/Kg of the extract increased it [P<0.05]. The total thiol concentration in hippocampal and cortical tissues of PTZ group was reduced while, MDA concentration was higher than control [p<0.05 - p<0.001]. Administration of the extract increased the total thiol and decreased the MDA concentrations [p<0.01 - p<0.001]. It is concluded that the hydro-alcoholic extract of NS possess beneficial effects on learning and memory impairments in repeated seizures model which is accompanied by antioxidant effects in the brain
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pentylenetetrazole
/
Seizures
/
Brain
/
Plant Extracts
/
Rats, Wistar
/
Oxidative Stress
/
Memory
Limits:
Animals
Language:
English
Journal:
Iran. J. Pharm. Res.
Year:
2015
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